SPOILER if you read on!!!

Anyway, by now you all should know Michelle is a double crossing low life so and so.

So let's get rid of her before that part of the story!

RPG's at her house don't work (I tried already), her windows are bullet proof, RPG proof, hell Nuclear bomb proof, so what else?

Come up with your ideas here..

Here's a few of mine:

When you are walking down the street with her, just punch her to death! Sure that is simple so..

Get fast car/bike, drive fast to end of pier and jump out at the last minute, and SPLASH

Pull out your automatic weapon, lock onto her head and have a blast?

Get a car bomb and blow it up while she is in it. You might also die though.

Yeah, sadly that is the best thing to do after you beat the game.

Would she get into an helicopter with you? You could drive way out to sea with her or fly up to the top of the Empire state building then bail leaving her in the chopper with no pilot